Construction and Validation of a Lung Cancer Risk Prediction Model for Non-Smokers in China.

ABSTRACT:

Background

About 15% of lung cancers in men and 53% in women are not attributable to smoking worldwide. The aim was to develop and validate a simple and non-invasive model which could assess and stratify lung cancer risk in non-smokers in China.

Methods

A large-sample size, population-based study was conducted under the framework of the Cancer Screening Program in Urban China (CanSPUC). Data on the lung cancer screening in Henan province, China, from October 2013 to October 2019 were used and randomly divided into the training and validation sets. Related risk factors were identified through multivariable Cox regression analysis, followed by establishment of risk prediction nomogram. Discrimination [area under the curve (AUC)] and calibration were further performed to assess

SUBMITTER: Guo LW 

PROVIDER: S-EPMC8764453 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature