Characterization of whole-brain task-modulated functional connectivity in response to nociceptive pain: A multisensory comparison study.

ABSTRACT: Previous functional magnetic resonance imaging (fMRI) studies have shown that brain responses to nociceptive pain, non-nociceptive somatosensory, visual, and auditory stimuli are extremely similar. Actually, perception of external sensory stimulation requires complex interactions among distributed cortical and subcortical brain regions. However, the interactions among these regions elicited by nociceptive pain remain unclear, which limits our understanding of mechanisms of pain from a brain network perspective. Task fMRI data were collected with a random sequence of intermixed stimuli of four sensory modalities in 80 healthy subjects. Whole-brain psychophysiological interaction analysis was performed to identify task-modulated functional connectivity (FC) patterns for each modality. Task-m

SUBMITTER: Li L 

PROVIDER: S-EPMC8764484 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature