CRF serum levels differentiate PTSD from healthy controls and TBI in military veterans.

ABSTRACT:

Background and objective

Posttraumatic stress disorder (PTSD) is a serious and frequently debilitating psychiatric condition that can occur in people who have experienced traumatic stessors, such as war, violence, sexual assault and other life-threatening events. Treatment of PTSD and traumatic brain injury (TBI) in veterans is challenged by diagnostic complexity, partially due to PTSD and TBI symptom overlap and to the fact that subjective self-report assessments may be influenced by a patient's willingness to share their traumatic experiences and resulting symptoms. Corticotropin-releasing factor (CRF) is one of the main mediators of hypothalamic pituitary adrenal (HPA)-axis responses in stress and anxiety.

Methods and results

We analyzed serum CRF levels in 230 participan

SUBMITTER: Ramos-Cejudo J 

PROVIDER: S-EPMC8764614 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature