A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage.

ABSTRACT: Across multiple sectors, including food, cosmetics and pharmaceutical industries, there is a need to predict the potential effects of xenobiotics. These effects are determined by the intrinsic ability of the substance, or its derivatives, to interact with the biological system, and its concentration-time profile at the target site. Physiologically-based kinetic (PBK) models can predict organ-level concentration-time profiles, however, the models are time and resource intensive to generate de novo. Read-across is an approach used to reduce or replace animal testing, wherein information from a data-rich chemical is used to make predictions for a data-poor chemical. The recent increase in published PBK models presents the opportunity to use a read-across approach for PBK modelling, tha

SUBMITTER: Thompson CV 

PROVIDER: S-EPMC8764633 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature