Photosynthetic assimilation of CO₂ regulates TOR activity.

ABSTRACT: The target of rapamycin (TOR) kinase is a master regulator that integrates nutrient signals to promote cell growth in all eukaryotes. It is well established that amino acids and glucose are major regulators of TOR signaling in yeast and metazoan, but whether and how TOR responds to carbon availability in photosynthetic organisms is less understood. In this study, we showed that photosynthetic assimilation of CO₂ by the Calvin-Benson-Bassham (CBB) cycle regulates TOR activity in the model single-celled microalga Chlamydomonas reinhardtii Stimulation of CO₂ fixation boosted TOR activity, whereas inhibition of the CBB cycle and photosynthesis down-regulated TOR. We uncovered a tight link between TOR activity and the endogenous level of a set of amino acids includi

SUBMITTER: Mallen-Ponce MJ 

PROVIDER: S-EPMC8764670 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature