Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk.

ABSTRACT:

Background

There is strong evidence that epigenetic age acceleration is associated with increased risk of later-life diseases and all-cause mortality. However, there is currently limited evidence that suggests accelerated epigenetic age is associated with dementia risk.

Objective

This study aims to clarify whether epigenetic biomarkers of accelerated aging can predict dementia risk, which is an important consideration as aging is the greatest risk factor for the disease.

Methods

DNA methylation was measured in peripheral blood samples provided by 160 participants from the ASPirin in Reducing Events in the Elderly study, including 73 pre-symptomatic dementia cases and 87 controls matched for age, sex, and smoking and education status. Epigenetic age was calculated usin

SUBMITTER: Fransquet PD 

PROVIDER: S-EPMC8764717 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature