NSAID use and unnatural deaths after cancer diagnosis: a nationwide cohort study in Sweden.

ABSTRACT:

Background

Cancer patients experience increased risk of death from accident and suicide. Cognitive impairment induced by cancer-related inflammation and stress-related psychiatric symptoms may be underlying mechanisms. We therefore studied the association between use of nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of these outcomes.

Methods

Following a cohort of 388,443 cancer patients diagnosed between October 2005 and December 2014 in Sweden, we ascertained dispense of aspirin or non-aspirin NSAIDs from 3 months before cancer diagnosis onward and defined the on-medication period as from date of drug dispense until the prescribed dosage was consumed. Follow-up time outside medicated periods and time from unexposed patients were defined as off-medication periods. W

SUBMITTER: Shen Q 

PROVIDER: S-EPMC8764760 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature