Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA).

ABSTRACT:

Background

DNA methylation, an epigenetic mechanism modulated by lifestyle and environmental factors, may be an important biomarker of complex diseases including cardiovascular diseases (CVD) and subclinical atherosclerosis.

Methods

DNA methylation in peripheral blood samples from 391 African-Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA) was assessed at baseline, and atherosclerosis was assessed 5 and 12 years later. Using linear mixed models, we examined the association between previously identified CpGs for coronary artery calcification (CAC) and carotid plaque, both individually and aggregated into methylation risk scores (MRS_CAC and MRS_carotid), and four measures of atherosclerosis (CAC, abdominal aorta calcification (AAC),

SUBMITTER: Ammous F 

PROVIDER: S-EPMC8764761 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature