Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma.

ABSTRACT:

Background

The immunotherapy with immune checkpoints inhibitors (ICI) has changed the life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients do not respond hence, the identification and validation of novel biomarkers of response to ICI is of crucial importance. Circulating extracellular vesicles (EVs) such as PD-L1⁺ EV mediate resistance to anti-PD1, instead the role of PD1⁺ EV is not fully understood.

Methods

We isolated the circulating EVs from the plasma of an observational cohort study of 71 metastatic melanoma patients and correlated the amount of PD-L1⁺ EVs and PD1⁺ EVs with the response to ICI. The analysis was performed according to the origin of EVs from the tumor and the immune cells. Subsequ

SUBMITTER: Serrati S 

PROVIDER: S-EPMC8764806 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature