Anxiolytic effects of silibinin and naringenin on zebrafish model: A preclinical study.

ABSTRACT:

Objective

Stress exacerbates the pathophysiology of major neurodegenerative disorders. In this study, the zebrafish (Danio rerio), the frequently used model for experimental studies of stress and other central nervous system disorders, was used to evaluate the anxiolytic potential of flavonoids, namely silibinin and naringenin on alleviating acute stress-induced anxiety.

Materials and methods

A molecular docking study with Molegro Virtual Docker software was done to assess the binding potential of flavonoids on serotonin and dopamine receptors. To determine the bioactivity and investigate the toxicity of the flavonoids, silibinin, and naringenin, brine shrimp lethality assay, and an acute toxicity study was conducted according to Organization for Economic Co-operation and De

SUBMITTER: Nachammai V 

PROVIDER: S-EPMC8764982 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature