11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans.

ABSTRACT: Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the development of related PET radiotracers. In this study, 11C-PABA PET imaging was used to accurately detect and monitor infections due to pyogenic bacteria in multiple clinically relevant animal models. 11C-PABA PET imaging selectively detected infections in muscle, intervertebral discs, and methicillin-resistant Staphylococcus aureus-infected orthopedic implants. In what we believe to be first-in-human studies in healthy participants, 11C-PABA was safe, well-tolerated, and had a favorable biodistribution, with low background activity in the lu

SUBMITTER: Ordonez AA 

PROVIDER: S-EPMC8765043 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature