Comparative secretome analysis of Staphylococcus aureus strains with different within-herd intramammary infection prevalence.

ABSTRACT: Staphylococcus aureus is a major pathogen causing intramammary infection and mastitis in dairy cows. S. aureus genotypes (GT) can differ significantly in their ability to diffuse and persist in the herd; while the association of virulence gene carriage with epidemiological behavior remains unclear, a role for secreted proteins has been postulated. We characterized the secretome of six S. aureus strains belonging to two genotypes with opposite within-herd prevalence, GTB (high) and GTS (low), corresponding to sequence types (ST) 8 and 398, by high-resolution tandem mass spectrometry and differential analysis with Proteome Discoverer. Data are available via ProteomeXchange with identifier PXD029571. Out of 720 identified proteins, 98 were unique or more abundant in GTB/S

SUBMITTER: Addis MF 

PROVIDER: S-EPMC8765078 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature