Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates In Vitro and in a Mouse Model of Pulmonary Infection.

ABSTRACT: The incidence of nontuberculous mycobacterial diseases in the United States is rising and has surpassed that of tuberculosis. Most notable among the nontuberculous mycobacteria is Mycobacteroides abscessus, an emerging environmental opportunistic pathogen capable of causing chronic infections. M. abscessus disease is difficult to treat, and the current treatment recommendations include repurposed antibiotics, several of which are associated with undesirable side effects. In this study, we have evaluated the activity of omadacycline, a new tetracycline derivative, against M. abscessus using in vitro and in vivo approaches. Omadacycline exhibited an MIC₉₀ of 0.5 µg/mL against a panel of 32 contemporary M. abscessus clinical isolates, several of which were resistant t

SUBMITTER: Nicklas DA 

PROVIDER: S-EPMC8765394 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature