Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women.

ABSTRACT:

Purpose

To investigate the association between serum complement components and age-related macular degeneration (AMD).

Patients and methods

A total of 118 AMD patients and age- and sex-matched 106 control subjects were included. Demographic data and the level of serum complement component (C)1q, C3 and C4 were evaluated. Based on sex, the subjects were stratified into male and female subgroups.

Results

The level of C1q (226.31±45.33mg/dL) was significantly higher and C3 (121.14±15.76mg/dL) was significantly lower than that in control group (200.03±38.54mg/dL) (128.42±19.81mg/dL) in the female AMD patients (p = 0.005, p = 0.045). Logistic regression showed that increased C1q (OR = 1.132, p = 0.016) and decreased C3 (OR = 0.960, p = 0.048) were independent risk factors

SUBMITTER: Ma Y 

PROVIDER: S-EPMC8765539 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature