Blood Biomarkers and 6- to 7-Year Childhood Outcomes Following Neonatal Encephalopathy.

ABSTRACT:

Objective

This study aimed to profile the cytokine/chemokine response from day 0 to 7 in infants (≥36 weeks of gestational age) with neonatal encephalopathy (NE) and to explore the association with long-term outcomes.

Study design

This was a secondary study of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network randomized controlled trial of whole body hypothermia for NE. Eligible infants with moderate-severe NE were randomized to cooling or normothermia. Blood spots were collected on days 0 to 1, 2 to 4, and 6 to 7. Twenty-four cytokines/chemokines were measured using a multiplex platform. Surviving infants underwent neurodevelopmental assessment at 6 to 7 years. Primary outcome was death or moderate-severe i

SUBMITTER: Pappas A 

PROVIDER: S-EPMC8765716 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature