Context-dependent relationships between locus coeruleus firing patterns and coordinated neural activity in the anterior cingulate cortex.

ABSTRACT: Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural networks via the release of norepinephrine (NE). However, the exact nature of these neuromodulatory effects on neural activity patterns in vivo is not well understood. Here, we show that in awake monkeys, LC activation is associated with changes in coordinated activity patterns in the anterior cingulate cortex (ACC). These relationships, which are largely independent of changes in firing rates of individual ACC neurons, depend on the type of LC activation: ACC pairwise correlations tend to be reduced when ongoing (baseline) LC activity increases but enhanced when external events evoke transient LC responses. Both relationships covary with pupil changes that reflect LC activation and arousal. These re

SUBMITTER: Joshi S 

PROVIDER: S-EPMC8765756 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature