Pathophysiology and Clinical Features of Neuropsychiatric Manifestations of Thyroid Disease.

ABSTRACT: Thyroid hormones (TH) have a cardinal role in the development of the central nervous system during embryogenesis and early infancy. However, the TH-responsive genes in the developing brain cease to respond to TH in adulthood. Nevertheless, thyroid dysfunction in adults is commonly associated with a host of cognitive and psychiatric problems. Cognitive decline, dysphoria, and depression are common manifestations of overt hypothyroidism while hyperthyroidism can cause agitation, acute psychosis, and apathy, especially in older people. Whereas levothyroxine treatment can reverse dementia in the setting of hypothyroidism, the effect of levothyroxine on depressive symptoms in subjects with subclinical hypothyroidism is controversial. The use of supraphysiologic doses of TH to treat depression r

SUBMITTER: Jurado-Flores M 

PROVIDER: S-EPMC8765786 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature