Dynamic expression of homeostatic ion channels in differentiated cortical astrocytes in vitro.

ABSTRACT: The capacity of astrocytes to adapt their biochemical and functional features upon physiological and pathological stimuli is a fundamental property at the basis of their ability to regulate the homeostasis of the central nervous system (CNS). It is well known that in primary cultured astrocytes, the expression of plasma membrane ion channels and transporters involved in homeostatic tasks does not closely reflect the pattern observed in vivo. The individuation of culture conditions that promote the expression of the ion channel array found in vivo is crucial when aiming at investigating the mechanisms underlying their dynamics upon various physiological and pathological stimuli. A chemically defined medium containing growth factors and hormones (G5) was previously shown to induce the growth

SUBMITTER: Formaggio F 

PROVIDER: S-EPMC8766406 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature