Construction of a Novel Ferroptosis-Related Gene Signature of Atherosclerosis.

ABSTRACT: Atheroclerosis refers to a chronic inflammatory disease featured by the accumulation of fibrofatty lesions in the intima of arteries. Cardiovasular events associated with atherosclerosis remain the major causes of mortality worldwide. Recent studies have indicated that ferroptosis, a novel programmed cell death, might participate in the process of atherosclerosis. However, the ferroptosis landscape is still not clear. In this study, 59 genes associated with ferroptosis were ultimately identified in atherosclerosis in the intima. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed for functional annotation. Through the construction of protein-protein interaction (PPI) network, five hub genes (TP53, MAPK1, STAT3

SUBMITTER: Huang T 

PROVIDER: S-EPMC8766414 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature