Brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury.

ABSTRACT: Cancer cells frequently co-opt molecular programs that are normally activated in specific contexts, such as embryonic development and the response to injury. Determining the impact of cancer-associated mutations on cellular phenotypes within these discrete contexts can provide new insight into how such mutations lead to dysregulated cell behaviors and subsequent cancer onset. Here we assess the impact of heritable BRCA2 mutation on embryonic development and the injury response using a zebrafish model (Danio rerio). Unlike most mouse models for BRCA2 mutation, brca2-mutant zebrafish are fully viable and thus provide a unique tool for assessing both embryonic and adult phenotypes. We find that maternally provided brca2 is critical for normal oocyte development and embryonic survival in zebra

SUBMITTER: Kouprianov VA 

PROVIDER: S-EPMC8766490 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature