Resting state functional connectivity provides mechanistic predictions of future changes in sedentary behavior.

ABSTRACT: Sedentary behaviors are increasing at the cost of millions of dollars spent in health care and productivity losses due to physical inactivity-related deaths worldwide. Understanding the mechanistic predictors of sedentary behaviors will improve future intervention development and precision medicine approaches. It has been posited that humans have an innate attraction towards effort minimization and that inhibitory control is required to overcome this prepotent disposition. Consequently, we hypothesized that individual differences in the functional connectivity of brain regions implicated in inhibitory control and physical effort decision making at the beginning of an exercise intervention in older adults would predict the change in time spent sedentary over the course of that intervention.

SUBMITTER: Morris TP 

PROVIDER: S-EPMC8766514 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature