Metabolomics of Dietary Acid Load and Incident Chronic Kidney Disease.

ABSTRACT:

Objective

Blood biomarkers of dietary intake are more objective than self-reported dietary intake. Metabolites associated with dietary acid load were previously identified in 2 chronic kidney disease (CKD) populations. We aimed to extend these findings to a general population, replicating their association with dietary acid load, and investigating whether the individual biomarkers were prospectively associated with incident CKD.

Methods

Among 15,792 participants in the Atherosclerosis Risk in Communities cohort followed up from 1987 to 1989 (baseline) to 2019, we evaluated 3,844 black and white men and women with dietary and metabolomic data in cross-sectional and prospective analyses. We hypothesized that a higher dietary acid load (using equations for potential renal acid

SUBMITTER: Tariq A 

PROVIDER: S-EPMC8766597 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature