Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD.

ABSTRACT:

Rationale & objective

The utility of conventional upper reference limits (URL) for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population.

Study design

Observational study.

Setting & participants

We studied participants of the Chronic Renal Insufficiency Cohort (CRIC) with CKD and no self-reported history of cardiovascular disease.

Exposure

Estimated glomerular filtration rate (eGFR).

Outcome

NT-proBNP and hsTnT at baseline.

Analytical approach

We described the proportion of participants abov

SUBMITTER: Bansal N 

PROVIDER: S-EPMC8766621 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature