Induction Therapy Followed by Surgery for Unresectable Thymic Epithelial Tumours.

ABSTRACT:

Background and objectives

The treatment of unresectable thymic epithelial tumours (TETs) remains controversial. Here, we present the efficacy and safety of induction therapy followed by surgery for unresectable TET.

Methods

Eighty-one patients with unresectable TETs treated with induction therapy followed by surgery were selected from a retrospective review of consecutive TETs from January 2005 to January 2021. Clinicopathological data were analyzed to assess tumour responses, resectability, adverse events, progression-free survival (PFS) and overall survival (OS).

Results

Induction therapy produced a major tumour response rate of 69.1%, a tumour response grade (TRG) 1-3 rate of 84.0% and an R0 resection rate of 74.1%. The most common toxic effects were all-grade neut

SUBMITTER: Wang S 

PROVIDER: S-EPMC8766658 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature