Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction.

ABSTRACT: This report integrates knowledge of in situ macromolecular structures and synaptic protein biochemistry to propose a unified hypothesis for the regulation of certain vesicle trafficking events (i.e., docking, priming, Ca²⁺-triggering, and membrane fusion) that lead to neurotransmitter secretion from specialized "active zones" of presynaptic axon terminals. Advancements in electron tomography, to image tissue sections in 3D at nanometer scale resolution, have led to structural characterizations of a network of different classes of macromolecules at the active zone, called "Active Zone Material'. At frog neuromuscular junctions, the classes of Active Zone Material macromolecules "top-masts", "booms", "spars", "ribs" and "pins" direct synaptic vesicle docking while "pins", "

SUBMITTER: Szule JA 

PROVIDER: S-EPMC8766674 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature