Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling.

ABSTRACT:

Background and aims

Ductular reaction (DR) expands in chronic liver diseases and correlates with disease severity. Besides its potential role in liver regeneration, DR plays a role in the wound-healing response of the liver, promoting periductular fibrosis and inflammatory cell recruitment. However, there is no information regarding its role in intrahepatic angiogenesis. In the current study we investigated the potential contribution of DR cells to hepatic vascular remodeling during chronic liver disease.

Approach and results

In mouse models of liver injury, DR cells express genes involved in angiogenesis. Among angiogenesis-related genes, the expression of Slit2 and its receptor Roundabout 1 (Robo1) was localized in DR cells and neoangiogenic vessels, respectively. The angi

SUBMITTER: Coll M 

PROVIDER: S-EPMC8766889 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature