Prospective associations between neighborhood violence and monocyte pro-inflammatory transcriptional activity in children.

ABSTRACT: Individuals exposed to persistent neighborhood violence are at increased risk for developing mental and physical health problems across the lifespan. The biological mechanisms underlying this phenomenon are not well understood. Thus, we examined the relationship between children's exposure to neighborhood violence and inflammatory activity, a process involved in the pathogenesis of multiple health problems. 236 children from the Chicago area participated in a two-year longitudinal study (mean age at baseline, 13.9 years; 67% female; 39% White, 34% Black, 33% Hispanic). Neighborhood violence was measured as the homicide frequency in a child's Census block group in the five years before study entry. Fasting blood was drawn at study entry and two years later (in eighth and tenth grade). The b

SUBMITTER: Miller GE 

PROVIDER: S-EPMC8766930 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature