Deoxycholic Acid and Risks of Cardiovascular Events, ESKD, and Mortality in CKD: The CRIC Study.

ABSTRACT:

Rationale & objective

Elevated levels of deoxycholic acid (DCA) are associated with adverse outcomes and may contribute to vascular calcification in patients with chronic kidney disease (CKD). We tested the hypothesis that elevated levels of DCA were associated with increased risks of cardiovascular disease, CKD progression, and death in patients with CKD.

Study design

Prospective observational cohort study.

Setting & participants

We included 3,147 Chronic Renal Insufficiency Cohort study participants who had fasting DCA levels. The average age was 59 ± 11 years, 45.3% were women, 40.6% were African American, and the mean estimated glomerular filtration rate was 42.5 ± 16.0 mL/min/1.73 m².

Predictor

Fasting DCA levels in Chronic Renal Insufficiency C

SUBMITTER: Frazier R 

PROVIDER: S-EPMC8767130 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature