Embryonic hyperglycemia perturbs the development of specific retinal cell types, including photoreceptors.

ABSTRACT: Diabetes is linked to various long-term complications in adults, such as neuropathy, nephropathy and diabetic retinopathy. Diabetes poses additional risks for pregnant women, because glucose passes across the placenta, and excess maternal glucose can result in diabetic embryopathy. While many studies have examined the teratogenic effects of maternal diabetes on fetal heart development, little is known about the consequences of maternal hyperglycemia on the development of the embryonic retina. To address this question, we investigated retinal development in two models of embryonic hyperglycemia in zebrafish. Strikingly, we found that hyperglycemic larvae displayed a significant reduction in photoreceptors and horizontal cells, whereas other retinal neurons were not affected. We also observe

SUBMITTER: Titialii-Torres KF 

PROVIDER: S-EPMC8767273 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature