Genome reorganization during emergence of host-associated Mycobacterium abscessus.

ABSTRACT: Mycobacterium abscessus is a rapid growing, free-living species of bacterium that also causes lung infections in humans. Human infections are usually acquired from the environment; however, dominant circulating clones (DCCs) have emerged recently in both M. abscessus subsp. massiliense and subsp. abscessus that appear to be transmitted among humans and are now globally distributed. These recently emerged clones are potentially informative about the ecological and evolutionary mechanisms of pathogen emergence and host adaptation. The geographical distribution of DCCs has been reported, but the genomic processes underlying their transition from environmental bacterium to human pathogen are not well characterized. To address this knowledge gap, we delineated the st

SUBMITTER: Bohr LL 

PROVIDER: S-EPMC8767326 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature