Cluster-specific gene markers enhance Shigella and enteroinvasive Escherichia coli in silico serotyping.

ABSTRACT: Shigella and enteroinvasive Escherichia coli (EIEC) cause human bacillary dysentery with similar invasion mechanisms and share similar physiological, biochemical and genetic characteristics. Differentiation of Shigella from EIEC is important for clinical diagnostic and epidemiological investigations. However, phylogenetically, Shigella and EIEC strains are composed of multiple clusters and are different forms of E. coli, making it difficult to find genetic markers to discriminate between Shigella and EIEC. In this study, we identified 10 Shigella clusters, seven EIEC clusters and 53 sporadic types of EIEC by examining over 17000 publicly available Shigella and EIEC genomes. We compared Shigella and EIEC accessory genomes to ide

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8767346 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature