Cryptosporidium felis differs from other Cryptosporidium spp. in codon usage.

ABSTRACT: Cryptosporidium spp. are important enteric pathogens in a wide range of vertebrates including humans. Previous comparative analysis revealed conservation in genome composition, gene content, and gene organization among Cryptosporidium spp., with a progressive reductive evolution in metabolic pathways and invasion-related proteins. In this study, we sequenced the genome of zoonotic pathogen Cryptosporidium felis and conducted a comparative genomic analysis. While most intestinal Cryptosporidium species have similar genomic characteristics and almost complete genome synteny, fewer protein-coding genes and some sequence inversions and translocations were found in the C. felis genome. The C. felis genome exhibits much higher GC content (39.6 %) than ot

SUBMITTER: Li J 

PROVIDER: S-EPMC8767354 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature