Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction.

ABSTRACT:

Key points

Muscle infiltration with adipose tissue (IMAT) is common and associated with loss of skeletal muscle strength and physical function across a diverse set of pathologies. Whether the association between IMAT and muscle weakness is causative or simply correlative remains an open question that needs to be addressed to effectively guide muscle strengthening interventions in people with increased IMAT. In the present studies, we demonstrate that IMAT deposition causes decreased muscle strength using mouse models. These findings indicate IMAT is a novel therapeutic target for muscle dysfunction.

Abstract

Intramuscular adipose tissue (IMAT) is associated with deficits in strength and physical function across a wide array of conditions, from injury to ageing to metabolic d

SUBMITTER: Biltz NK 

PROVIDER: S-EPMC8767374 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature