Inflammatory Subtypes in Antipsychotic-Naive First-Episode Schizophrenia are Associated with Altered Brain Morphology and Topological Organization.

ABSTRACT:

Background

Peripheral inflammation is implicated in schizophrenia, however, not all individuals demonstrate inflammatory alterations. Recent studies identified inflammatory subtypes in chronic psychosis with high inflammation having worse cognitive performance and displaying neuroanatomical enlargement compared to low inflammation subtypes. It is unclear if inflammatory subtypes exist earlier in the disease course, thus, we aim to identify inflammatory subtypes in antipsychotic naïve First-Episode Schizophrenia (FES).

Methods

12 peripheral inflammatory markers, clinical, cognitive, and neuroanatomical measures were collected from a naturalistic study of antipsychotic-naïve FES patients. A combination of unsupervised principal component analysis and hierarchical clustering wa

SUBMITTER: Hoang D 

PROVIDER: S-EPMC8767408 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature