Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults.

ABSTRACT:

Background

Surfactant Protein D (SP-D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP-D levels in bronchoalveolar lavage samples decrease and serum levels increase in patients suffering from asthma, possibly due to a combination of induced SP-D synthesis and decreased air-blood barrier integrity. The aims of this study were to investigate whether serum levels of SP-D and common variants in the SP-D gene were associated with asthma in adolescents and young adults.

Methods

Prospective observational study including 449 adolescents and young adults (age 11-27 years) previously diagnosed with asthma during a 2-year period from 2003 to 2005 (0-16 years). At

SUBMITTER: Hoffmann-Petersen B 

PROVIDER: S-EPMC8767520 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature