CD4⁺/IL‑4⁺ lymphocytes of the lamina propria and substance P promote colonic protection during acute stress.

ABSTRACT: Life stress may influence symptom onset and severity in certain gastrointestinal disorders in association with a dysregulated intestinal barrier. It has been widely accepted that stress triggers the hypothalamus‑pituitary‑adrenal (HPA) axis, releasing corticosterone, which promotes intestinal permeability. In response, colonic inflammation alters mucosal immune homeostasis and destroys the colonic architecture, leading to severe intestinal diseases. Endogenous substance P (SP) does not inhibit the initial extent of the HPA axis response to restraint stress, but it reduces the duration of the stress, suggesting that SP plays an important role in the transition between acute and chronic stress. The present study aimed to investigate the effect of two groups of mice exposed to stress, includi

SUBMITTER: Arciniega-Martinez IM 

PROVIDER: S-EPMC8767552 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature