NETosis in Long-Term Type 1 Diabetes Mellitus and Its Link to Coronary Artery Disease.

ABSTRACT:

Background

Neutrophil extracellular traps NETs have been linked to glucose and the pathogenesis of type 1 diabetes mellitus (T1DM). NETs also play a role in vascular inflammation and the development of coronary artery disease (CAD). The role of NETs in CAD progression in patients with long-term T1DM is unclear. We aimed to 1) investigate whether levels of circulating NETs markers were elevated in long-term T1DM subjects compared to controls, and 2) explore whether levels of NETs were related to the presence of CAD.

Material and methods

102 patients with > 45 years of T1DM and 75 age-matched controls were enrolled in a cross-sectional study. Median age was 62 years. Computed tomography coronary angiography (CTCA) was performed in 148 subjects without established coronary hear

SUBMITTER: Aukrust SG 

PROVIDER: S-EPMC8767558 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature