Ontology highlight
ABSTRACT:
SUBMITTER: Bruzguliene J
PROVIDER: S-EPMC8767561 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20220112
A convenient and efficient synthesis of novel achiral and chiral heterocyclic amino acid-like building blocks was developed. Regioisomeric methyl 5-(<i>N</i>-Boc-cycloaminyl)-1,2-oxazole-4-carboxylates were prepared by the reaction of β-enamino ketoesters (including azetidine, pyrrolidine or piperidine enamines) with hydroxylamine hydrochloride. Unambiguous structural assignments were based on chiral HPLC analysis, <sup>1</sup>H, <sup>13</sup>C, and <sup>15</sup>N NMR spectroscopy, HRMS, and sin ...[more]