Tenacibactins K-M, cytotoxic siderophores from a coral-associated gliding bacterium of the genus Tenacibaculum.

ABSTRACT: HPLC/DAD-based chemical investigation of a coral-associated gliding bacterium of the genus Tenacibaculum yielded three desferrioxamine-class siderophores, designated tenacibactins K (1), L (2), and M (3). Their chemical structures, comprising repeated cadaverine-succinic acid motifs terminated by a hydroxamic acid functionality, were elucidated by NMR and negative MS/MS experiments. Compounds 1-3 were inactive against bacteria and a yeast but displayed cytotoxicity against 3Y1 rat embryonic fibroblasts and P388 murine leukemia cells at GI₅₀ in submicromolar to micromolar ranges. Their iron-chelating activity was comparable to deferoxamine mesylate.

SUBMITTER: Igarashi Y 

PROVIDER: S-EPMC8767563 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature