Extracellular cAMP: The Past and Visiting the Future in cAMP-Enriched Extracellular Vesicles.

ABSTRACT: It is recently discovered that the cyclic nucleotide, cyclic adenosine monophosphate (cAMP) can be enriched in the extracellular vesicles (EVs) isolated from endothelial cells. In the current perspective a historical context for the discovery of the extracellular cAMP is provided. The story of extracellular cAMP through investigations addressing the molecule's role in the adenosine pathway is followed, which is widespread in mammalian physiology. The adenosine pathway mediates normal physiological conditions such as renin release, phosphate transport, etc., and participates in pathological conditions such as bronchoconstriction of the airways. Furthermore, adenosine mediated biological pathways are regulated via the receptor mediated intracellular cAMP pathway in mammalian cells. It then s

SUBMITTER: Bhadra A 

PROVIDER: S-EPMC8767638 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature