Identification of key biomarkers in steroid-induced osteonecrosis of the femoral head and their correlation with immune infiltration by bioinformatics analysis.

ABSTRACT:

Objective

This study aimed to identify key diagnostic markers and immune infiltration of (SONFH) by bioinformatics analysis.

Methods

Related SONFH datasets were downloaded from the Gene Expression Omnibus (GEO) database. First, we identified the differentially expressed genes (DEGs) and performed the functional enrichment analysis. Then weighted correlation network analysis (WGCNA) and the MCODE plug-in in Cytoscape were used to identify the diagnostic markers of SONFH. Finally, CIBERSORT was used to analyze the immune infiltration between SONFH and healthy controls, and the correlation between infiltrating immune cells and diagnostic markers was analyzed.

Results

TYROBP, TLR2, P2RY13, TLR8, HCK, MNDA, and NCF2 may be key diagnostic markers of SONFH. Immune cell infil

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8767711 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature