N6-Methyladenosine-Related lncRNAs as potential biomarkers for predicting prognoses and immune responses in patients with cervical cancer.

ABSTRACT:

Background

Several recent studies have confirmed epigenetic regulation of the immune response. However, the potential role of RNA N6-methyladenosine (m⁶A) modifications in cervical cancer and tumour microenvironment (TME) cell infiltration remain unclear.

Results

We evaluated and analysed m⁶A modification patterns in 307 cervical cancer samples from The Cancer Genome Atlas (TCGA) dataset based on 13 m⁶A regulators. Pearson correlation analysis was used to identify lncRNAs associated with m⁶A, followed by univariate Cox regression analysis to screen their prognostic role in cervical cancer patients. We also correlated TME cell infiltration characteristics with modification patterns. We screened six m⁶A-associated lncRNAs

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8767716 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature