The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients.

ABSTRACT:

Background

Persistence of antibodies to SARS-CoV-2 viral infection may depend on several factors and may be related to the severity of disease or to the different symptoms.

Methods

We evaluated the antibody response to SARS-CoV-2 in personnel from 9 healthcare facilities and an international medical school and its association with individuals' characteristics and COVID-19 symptoms in an observational cohort study. We enrolled 4735 subjects (corresponding to 80% of all personnel) for three time points over a period of 8-10 months. For each participant, we determined the rate of antibody increase or decrease over time in relation to 93 features analyzed in univariate and multivariate analyses through a machine learning approach.

Results

Here we show in individuals posit

SUBMITTER: Levi R 

PROVIDER: S-EPMC8767777 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature