Reactogenicity and immunogenicity of heterologous prime-boost immunization with COVID-19 vaccine.

ABSTRACT:

Background

The objective of the present work was to assess the reactogenicity and immunogenicity of heterologous COVID-19 vaccination regimens in clinical trials and observational studies.

Methods

PubMed, Cochrane Library, Embase, MedRxiv, BioRxiv databases were searched in September 29, 2021. The PRISMA instruction for systemic review was followed. Two reviewers independently selected the studies, extracted the data and assessed risk of bias. The quality of studies was evaluated using the New Castle-Ottawa and Cochrane risk of instrument. The characteristics and study outcome (e.g., adverse events, immune response, and variant of concern) were extracted.

Results

Nineteen studies were included in the final data synthesis with 5 clinical trials and 14 observational stu

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC8767802 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature