Game theory applications in host-microbe interactions toward disease manifestation: Mycobacterium tuberculosis infection as an example.

ABSTRACT:

Objectives

Game theory describes the interactions between two players and the pay-off from winning, losing, or compromising. In the present study, Mycobacterium tuberculosis (Mtb)-host interactions were used as an example for the application of game theory to describe and predict the different outcomes of Mtb-infection and introducing target molecules for use in protection or therapy.

Materials and methods

The gene expression for eight main markers (CCR1, CCR2, IDO, Tbet, TGFβ, iNOS, MMP3, MMP9) of host response and three Mtb virulence factors (Ag85B, CFP-10, ESAT-6) were assessed in broncho-alveolar lavage of TB⁺ and TB^- patients.

Results

The players' strategies in the "Nash equilibrium", showed that Ag85B is the main

SUBMITTER: Sharebiani H 

PROVIDER: S-EPMC8769512 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature