Estimating mouthing exposure to chemicals in children's products.

ABSTRACT:

Background

Existing models for estimating children's exposure to chemicals through mouthing currently depends on the availability of chemical- and material-specific experimental migration rates, only covering a few dozen chemicals.

Objective

This study objective is hence to develop a mouthing exposure model to predict migration into saliva, mouthing exposure, and related health risk from a wide range of chemical-material combinations in children's products.

Methods

We collected experimental data on chemical migration from different products into saliva for multiple substance groups and materials, identifying chemical concentration and diffusion coefficient as main properties of influence. To predict migration rates into saliva, we adapted a previously developed migrat

SUBMITTER: Aurisano N 

PROVIDER: S-EPMC8770116 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature