RNA profiles reveal signatures of future health and disease in pregnancy.

ABSTRACT: Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden¹. Yet the ability to assess underlying pathophysiology before clinical presentation to enable identification of pregnancies at risk remains elusive. Here we demonstrate the ability of plasma cell-free RNA (cfRNA) to reveal patterns of normal pregnancy progression and determine the risk of developing pre-eclampsia months before clinical presentation. Our results centre on comprehensive transcriptome data from eight independent prospectively collected cohorts comprising 1,840 racially diverse pregnancies and retrospective analysis of 2,539 banked plasma samples. The pre-eclampsia data include 524 samples (72 cases and 452 non-cases) from two diverse independent cohorts collected 1

SUBMITTER: Rasmussen M 

PROVIDER: S-EPMC8770117 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature