Characteristics of the Immune Cell Infiltration Landscape in Gastric Cancer to Assistant Immunotherapy.

ABSTRACT: Background: Gastric cancer (GC) was usually associated with poor prognosis and invalid therapeutical response to immunotherapy due to biological heterogeneity. It is urgent to screen reliable indices especially immunotherapy-associated parameters that can predict the therapeutic responses to immunotherapy of GC patients. Methods: Gene expression profile of 854 GC patients were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets (GSE84433) with their corresponding clinical and somatic mutation data. Based on immune cell infiltration (ICI) levels, molecular clustering classification was performed to identify subtypes and ICI scores in GC patients. After functional enrichment analysis of subtypes, we further explored the correlation between I

SUBMITTER: Li C 

PROVIDER: S-EPMC8770548 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature