The oral microbiome in relation to pancreatic cancer risk in African Americans.

ABSTRACT:

Background

African Americans have the highest pancreatic cancer incidence of any racial/ethnic group in the United States. The oral microbiome was associated with pancreatic cancer risk in a recent study, but no such studies have been conducted in African Americans. Poor oral health, which can be a cause or effect of microbial populations, was associated with an increased risk of pancreatic cancer in a single study of African Americans.

Methods

We prospectively investigated the oral microbiome in relation to pancreatic cancer risk among 122 African-American pancreatic cancer cases and 354 controls. DNA was extracted from oral wash samples for metagenomic shotgun sequencing. Alpha and beta diversity of the microbial profiles were calculated. Multivariable conditional logistic

SUBMITTER: Petrick JL 

PROVIDER: S-EPMC8770575 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature