Ontology highlight
ABSTRACT:
SUBMITTER: Kanakkanthara A
PROVIDER: S-EPMC8770599 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Kanakkanthara Arun A Hou Xiaonan X Ekstrom Thomas L TL Zanfagnin Valentina V Huehls Amelia M AM Kelly Rebecca L RL Ding Husheng H Larson Melissa C MC Vasmatzis George G Oberg Ann L AL Kaufmann Scott H SH Mansfield Aaron S AS Weroha S John SJ Karnitz Larry M LM
Cancer research 20211122 2
PARP inhibitors (PARPi) have activity in homologous recombination (HR) repair-deficient, high-grade serous ovarian cancers (HGSOC). However, even responsive tumors develop PARPi resistance, highlighting the need to delay or prevent the appearance of PARPi resistance. Here, we showed that the ALK kinase inhibitor ceritinib synergizes with PARPis by inhibiting complex I of the mitochondrial electron transport chain, which increases production of reactive oxygen species (ROS) and subsequent inducti ...[more]